Aug

24

1

LO Introduction; overview of neurons and nervous systems (bits of Ch's.1,8,16,22 & 23)

26

2

LO Cell biology of neurons, microscopy: shapes & relations; cerebellar cortex eample

28

3

LO " (cont'd.) the 'Neuron Doctrine', developmental and physiological issues

31

4

LO " (cont'd.) sub-cellular organelles, cytoskeletal components, transport

Sep

02

5

LO Electrical nature of nerve signals: a little history and some electrical basics

04

6

DY Model systems and organisms, Imaging the brain

07

<No class, Labor Day Holiday>

09

7

LO The nerve signal: significant early experiments: new technology and key facts

11

8

LO Elaboration of key facts: phenomena of electrical stimulation and more basics

14

9

LO " (cont'd.): mapping nerve currents; history of the AP; the 'membrane hypothesis'

16

10

LO Membrane hypothesis of nerve impulse and its implications: 'local currents' and extracellularly recorded action potentials (Ch.7)

18

11

LO " (cont'd.): AP propagation in axons; simple cable theory

21

MIDTERM EXAM 1 coverning material of lectures 1 through 10

23

12

LO Ionic basis of membrane potentials: the resting potential (parts of Ch's.2 & 5)

25

13

LO " (cont'd): an electrical-circuit model; membrane capacitance (more of Ch.7)

28

14

LO " (cont'd.): Nernst equation and multi-ion membrane potentials

30

15

LO Ionic basis of the action potential: conceptual background (more of Ch.5)

Oct

02

16

LO " (cont'd.): Na-hypothesis; Hodgkin-Huxley 'voltage-clamp' experiments (Ch.6)

05

17

LO " (cont'd.): voltage-sensitive ion conductances; AP mechanisms and phenomena

07

18

DY Biochemistry of ion channels I (parts of Ch 2)

09

19

DY Biochemistry of ion channels II (Ch. 2 & 3)

12

<No class, Fall Break>

14

<No class, Fall Break>

16

<No class, Fall Break>

19

20

DY Biochemistry of ion channels III (Ch. 3)

21

21

DY Chemical versus electrical signals (pp. 158 —160 of Ch. 9)

23

22

DY Chemical synaptic transmission: post-synaptic mechanisms I (Ch.9)

26

MIDTERM EXAM 2 covering material of lectures 11 through 21

28

23

DY Chemical synaptic transmission: post-synaptic mechanisms II (Ch.9)

30

24

DY Indirect mechanisms of synaptic transmission I (Ch. 10)

Nov

02

25

DY Indirect mechanisms of synaptic transmission II (Ch. 10)

04

26

DY Transmitter release I. Calcium and quantal nature of release (Ch. 11)

06

27

GE Transmitter release II. Molecular biology of synaptic vesicle exocytosis (Ch. 11, 13)

09

28

GE Synaptic vesicle recycling (Ch. 13)

11

29

DY Neurotransmitter biochemistry (Ch's. 11 & 13, cont'd.)

13

30

DY Neurotransmitters in the central nervous system (Ch. 14)

16

31

DY Autonomic nervous system (Ch. 16)

18

32

DY Synaptic plasticity (Ch.12)

20

33

LO Voltage-gated channels revisited, a sampling of others: frequency regulation, pacemakers, et al. (IA, IK(Ca), Ih, Iir); the cardiac AP

23

MIDTERM EXAM 3 covering material of lectures 22 through 32

25

34

DY Transduction of sensory stimuli I. Mechanoreception (Ch. 17)

27

<No class, Thanksgiving Break >

30

35

DY Transduction of sensory stimuli II. Chemoreception and thermoreception (Ch. 17)

Dec

02

36

DY Processing of somatosensory signals (Ch 18)

04

37

DY Transduction and signaling in the retina (Ch 19)

07

38

DY Signaling in the lateral geniculate nucleus and 1° visual cortex (Ch 20)

09

39

DY Cellular mechanisms of motor control (Ch 22)

11

40

DY Channelopathies