Biology 3240 Intro Cellular Neurobiol, Fall '09
Suggested Readings

Following are the lists of readings suggested in lectures. A key to the abreviations used for references in the lists is at the top.

Except for the three cases noted, all the references are on Reserve at Marriott Library under the Biology 3240 heading

We'll try to keep these lists updated.

Larry Okun, Doju Yoshikami

(to Key Words & Concepts instead:  Lectures 1-10   Lectures 11-21   Lectures 22-32   Lectures 33-40)

Abbreviations for References:

NMWF4:     Nicholls, J.G., Martin, A.R., Wallace, B.G., and Fuchs, P.A. From Neuron to Brain, 4th edition. Sinauer Associates, 2001. (recommended text)

Aidley4:    Aidley, D. J. The Physiology of Excitable Cells, 4th edition Cambridge University Press, 1998

Alb2:    Alberts, B., et al. Molecular Biology of the Cell, 2nd edition. Garland Publications, 1989

Alb3, Alb4, Alb5:     3rd edition (1994), 4th edition (2002), and 5th edition (2007) of above (not on Reserve but possibly in some students' collections)

Alb ECB:    Alberts, B., et al. Essential Cell Biology. Garland Publications, 1998 (not on Resere; used in Biol. 2020 in previous years)

Alb ECB2, ECB3:     2nd edition (2004), and 3rd edition (2009) of above (not on Resere; used in Biol. 2020 in recent years; copies of latest edition likely on Reserve under Biol. 2020))

Ashcroft:    Ascroft, F. M. Ion Channels and Disease: Channelopathies. Academic Press, 2000.

D.G.Nicholls:     Nicholls, D. G. Proteins, Transmitters and Synapses. Blackwell Scientific Publications, 1994.

Hille3:     Hille, B. Ionic Channels of Excitable Membranes, 3rd edition. Sinauer Associates, 2001.

KSJ Ess:     Kandel, E.R., Schwartz, J.H., and Jessell, T.M. Essentials of Neural Science and Behavior. Appleton and Lange, 1995.

KSJ4 (Princ):     Kandel, E. R., Schwartz, J. H., and Jessell, T. M. Principles of Neural Science, 4th edition. McGraw Hill, 2000.

Matthews CellPhys3:   Matthews, G. G. Cellular Physiology of Nerve and Muscle, 3rd edition. Blackwell Scientific Publications, 1998.

Matthews Neurobiol2:   Matthews, G. G. Neurobiology: Molecules, Cells, and Systems, 2nd edition. Blackwell Scientific Publications, 2001.

PPW3:    Peters, A., Palay, S. L., and Webster, H. The Fine Structure of the Nervous System, 3rd edition. Oxford University Press, 1991.

Purv2:     Purves, D., et al., eds. Neuroscience, 2nd edition. Sinauer Associates, 2001.

Purv3:     Purves, D., et al., eds. Neuroscience, 3rd edition. Sinauer Associates, 2004.

Purv4:     Purves, D., et al., eds. Neuroscience, 4th edition. Sinauer Associates, 2008.

Reichert     Reichert, H. Introduction to Neurobiology. Oxford Universiy Press, 1992

Shep5:     Shepherd, G.M. The Synaptic Organization of the Brain, 5th edition. Oxford University Press 2004.

Lecture 1

NMWF4 Ch. 1, pp.4-9             neural cells
                Ch. 8, pp.134-137     glia (rest of chapter is excellent summary of astroglial function, for later reading)
                Ch.16, pp.315-317    autonomic nervous system
                Ch.22, pp.453-456    spinal-reflex circuits (skip details of stretch receptors and gamma motorneuron function)
                                                    (Note: Fig.22.9 has an error. Can you find it?)
                Ch.23, pp.479-484    embryonic origins

KSJ Ess Ch. 2, pp.21-31          neural cells, nervous system
               Ch.28, pp.515-523     spinal-reflex circuits

Purv2   Ch. 1, pp.1-12                 neural cells, nervous system, a spinal-reflex circuit
             Ch.21, pp.445 Fig.21      sympathetic & parasympathetic parts of autonomic nervous system
or
Purv3   Ch. 1, pp.1-16                   neural cells, nervous system, a spinal-reflex circuit
             Ch.20, pp.472 Fig.20.1     sympathetic & parasympathetic parts of autonomic nervous system
or
Purv4   Ch. 1, pp.1-16                   neural cells, nervous system, a spinal-reflex circuit
             Ch.21, pp.517 Fig.21.1     sympathetic & parasympathetic parts of autonomic nervous system

D.G.Nicholls pp. 3-6             neurons, glia
                      pp. 10-14         nervous-system organization
                      includes p.13   cerebellar cortex

Lecture 2

PPW3 pp.3-7   The Neuron Theory, history & issues

KSJ4 (Princ) pp. 835-838   cerebellar cortex architecture and circuitry

D.G.Nicholls p. 13   cerebellar cortex architecture and circuitry (1-page review!)

Shep5 pp. 271-278   cerebellar cortex architecture (with some of Cajal's original illustrations
                                  from Golgi-stained preparations)
           pp. 284-286   cerebellar cortex circuitry

from Lecture 1:

Purv2 p.628     the Duchenne smile, an example of the 'Boxes' feature of this text,
                         entertaining and interesting additions worth browsing.
or
Purv3 p.690     same
or
Purv4 pp. 735-736   same

Lecture 3

for Lectures 4 & 5:

KSJ Ess Ch. 3   neuron structure
               Ch. 4   neuron cell biology

Alb2 pp.1059-1065   neuron structure and cell biology

Lecture 4

Alb2 (or 3rd, 4th, or 56h eds.) index   cell biology topics;
      e.g. intracellular membrane-bound compartments (smooth ER, rough ER, Golgi),
      cytoskeletal molecules (actin, neurofilaments, microtubules).
      If more detail is desired on any of these topics, these excellent and athoritative texts
      (2nd, 3rd, 4th, or 5th editions) are hard to beat.
or
AlbECB (1st, 2nd, or 3rd eds.) index   (same topics) -- condensed versions of above texts, also excellent

PPW3 frontispiece   illustrations of key neuronal features seen at light-microscopic level

added for those interested:

KSJ4 (Princ) Ch. 42   cerebellum, structure and function
      (an almost encyclopedic text with strong clinical perspective)

Lecture 5

Alb2 Ch.11     cytoskeletal elements (review topics of interest)
or
editions 3, 4, or 5 of same text   (corresponding chapter on cytoskeletal elements)
or
Alb ECB eds. 1, 2, or 3   (corresponding chapter on cytoskeletal elements)

NMWF4 pp. 256-259     axonal transport
NMWF4 pp. 526-528     for review: axotomy consequences -- Wallerian degeneration, chromatiolysis

KSJ Ess pp.62-69 of Ch.4     cytoskeletal elements, axonal transport
(Note: Paragraph re: neurofilaments, pp.65,67, has numerous errors.)

(for Lecture 7 and later)

NMWF4 App.A              review of electrical-circuit basics

KSJ4 (Princ) App.A     similar review, different perspective

Lecture 6

NMWF4   Figures 15.1 (p. 294) and 15.2 (p. 295)   CNS of the Leech.

NMWF4   Book cover & Fig. 1.7 (p. 12)   Brain imaging.

Purv3 Box A (pp. 25-27)   Brain imaging techniques. Note error in 2nd paragraph on p. 26:
                                            should be not 'two positrons' but 'two gamma photons.'
or
Purv4 Box 1A (pp. 19-21)   same. Error is on p. 20.

KSJ4 (Princ) Boxes 19-3 & 19-4 (pp. 370-377)   a more detailed account of brain imaging

Lecture 7

(as given in Lecture 5)

NMWF4 App.A              review of electrical-circuit basics

KSJ4 (Princ) App.A     similar review, different perspective

add for Lecture 8:

Aidley4 pp.37-40     phenomena associated with electrical stimulation of nerve

Lecture 8

(for Lectures 9-10;
alternatives and some other suggestions will be given in Lect. 9
as will a comment on the order of topics in texts vs. their order in lectures)

NMWF4 Ch.7, pp.113-124     impulse propagation, local circuit theory, cable theory, role of myelin
                      p.125 Box 7.2     compound AP
                   skip pp.118-121    membrane capacitance (to be covered later)

Lecture 9

(for Lectures 9-10)

as given in Lecture 8 note above:

NMWF4 Ch.7, pp.113-124     impulse propagation, local circuit theory, cable theory, role of myelin
                      p.125 Box 7.2     compound AP
                   skip pp.118-121    membrane capacitance (to be covered later)

alternatives:

KSJ Ess Ch.9, pp.153-end   same
or
KSJ4 (Princ) Ch.8, pp.143-end   same

Purv3 Ch.3, pp.56, 58-61   same
                                  p. 63   myelin
or
Purv4 Ch.3, pp.49, 51-54   same
                        ;  pp.56-58   myelin
In either, skip capacitance part of 'Box C' and text re: 'channels.'
Also ignore 'ion shuttling' idea (Purv3 p.60, Purv4 p.54) -- ions *do* move to carry current,
just not as fast as electrical effects; cf. water in a full hose: 'news' that the valve has been turned
on gets to the end long before any water from the valve does.

other -- some aspects not covered in texts above and a nice review of cable theory:

Aidley4 pp.46-48     local circuit theory, Hodgkin's 1937 experiments (tests for 'local currents'), extracellular APs
                                  (ignore equations)

Alb2 pp.1066-1068, skip p.1067     cable theory

Lecture 10

(for review)

Reichert Ch.2   good, brief coverage of several topics; suggestions for current review follow:
         pp.13-17   neuron structure (for earlier lectures)
         pp.29-33   cable theory (skip capacitance)

Lecture 11

(for Lectures 12-13)

NMWF4 Ch.2 pp.34-36     equilibrium potentials, Nernst equation, 'g-view'
                                Ch.5     resting potential (RP) mechanism, equilibrium potentials

Alternatives:

KSJ Ess Ch.8     same

KSJ4 (Princ) Ch.7     same

Purv3 Ch.2 pp. 34-43     same
    (skip pp.38-40, multi-ion case)
or
Purv4 Ch.2 pp. 28-36     same
    (skip pp.32-33, multi-ion case)

Alb2 pp. 314-316       same
or
Alb3 pp. 524-527       same
or
Alb4 pp. 633-635       same
or
Alb5 pp. 669-671       same
or
AlbECB pp. 391-394   same (brief, introductory)
or
AlbECB2 pp. 408-410   same (brief, introductory)
    (Note: Avoid possible confusion in the AlbECB and AlbECB2 references between
   an 'equilibrium' and a 'steady state'. They not the same.)

Other -- some aspects not covered in texts above and nice reviews of several topics:

Matthews CellPhys3 pp.13-22     osmotic and tonic balance
or
Matthews Neurobiol2: pp.42-49     same

Reichert Ch.2   (good, brief reviews):
         pp.20-28     RP mechanism
         pp.43-47     AP propagation

Lecture 12

(for Lecture 13)

NMWF4 Ch.7, pp.118-121     membrane capacitance, parallel RC circuits

Alternatives:

KSJ Ess Ch.9, pp.149-153     same

KSJ4 (Princ) Ch.8, pp.142-143 & App.A     same
    (Note: There is an error on p.1281 of App.A. An incorrect explanation is given for
    why the electrical force is constant between the plates of a parallel-plane-plate
    capacitor. The force iseffectively constant when the distance between the plates
    is small compared to their area, but for a quite different reason, outlined in class. For
    the same reason, the force is also constant near a singlecharged plate of large area.)

Purv3 Ch.3, pp.56, 58 (incl. Fig.3.10), 60-61 (incl. Box C with capacitance)     same
or
Purv4 Ch.3, pp.49, 51-54 (incl. Fig.3.10 and Box 3C with capacitance), 56     same

Lecture 13

no new listings

Lecture 14

(for Lectures 15-17)

NMWF4 Ch.6 pp.91-103   active-site mechanisms, Hodgkin-Huxley mechanisms & experiments, Voltage-clamp
                                                  (skip sections re: gating currents, channels)

Alternatives:

KSJ Ess Ch.10 pp.160-173         same

KSJ4 (Princ) Ch.9 pp.150-158     same

Purv3 Ch.3 pp.47-56       same
or
Purv4 Ch.3 pp.41-49       same

Brief reviews:

Aidley4 pp.54-63   Hodgkin-Huxley experiments

Reichert p.42          same

Alb2 pp.1068-1074       active-site mechanisms (brief, introductory)
or
Alb3 pp.528-532       same
or
Alb4 pp.638-643       same
or
Alb5 pp.676-680       same
or
AlbECB pp.395-397 & Fig.12-33 on p.398   same
or
AlbECB2 pp.411-414   same (with partial 'how-we-know' experimental background)

Lecture 15

no new listings

Lecture 16

no new listings

Lecture 17

(for Lecture 18)

NMWF4 Ch.2

Lecture 18

(for Lecture 19)

NMWF4 Ch.2 (cont'd.) & Ch.3

Lecture 19

(for Lecture 20)

NMWF4 Ch.3 (cont'd)
                Ch.6 pp.105-108

Lecture 20

(for Lecture 21)

NMWF4 Ch.7 pp.128 (bottom)-131   gap junctions
                Ch.9 pp.158-160 (top)     electrical synaptic transmission

Lecture 21

(for Lecture 22)

NMWF4 Remainder of Ch.9 from start (p.155) to end (p.176) 'direct' synaptic transmission
  (Note: Section on Synaptic Structure, p. 160 bottom to p. 162 top, will be covered in a later lecture.)

Lecture 22

(for Lecture 23)

NMWF4 Ch.9 (cont'd)

Lecture 23

(for Lectures 24 & 25)

NMWF4 Ch.10

Lecture 24

(for Lecture 25)

NMWF4 Ch.10 (cont'd) and start Ch.11

Lecture 25

(for Lecture 26)

NMWF4 Ch.11 (cont'd)

Lecture 26

no new listings

Lecture 27

PPW3 Fig 5-6

Comment:The textbooks provide good background, but note the date of the text and that some models on vesicle fusion presented in the texts are no longer the prevailing view. If interested in further reading, consider looking up the references cited at the bottom of the slides from the lecture. Any computer with access to the University of Utah libraries can gain access to the references cited on the slides.

NWMF4 pp.261-263

Purv3 pp.110-113, p.114 Fig. 5.14, p.115 Box C
or
Purv4 pp.102-105, incl. Fig. 5.14, p.106 Box C

Aidley4 pp.188-190

KSJ4 (Princ) pp.262-267, 270-274

Alb2, Alb3, Alb4, or Alb5 for reviews of electron microscopy, X-ray crystallography, making transgenes, lipids

Lecture 28

NMWF4 pp.213-224, 263 morphological evidence of synaptic vesicle exo and endocytosis

Lecture 29

NMWF4 Ch.11 (concluded)
                Ch.13

(for Lecture 30)

NMWF4 Ch.13 (cont'd.)
                Ch.14

Lecture 30

(for Lecture 31)

NMWF4 Ch.16

Lecture 31

(for Lecture 32)

NMWF4 Ch.12

Lecture 32

(Readings for Lecture 33 will be provided with that lecture's entry.)

(for Lecture 34)

NMWF4 Ch.17

Lecture 33

Alb2 pp. 1088-1090   roles of IK(Hodgkin-Huxley 'delayed rectifier'), IA, IK(Ca) currents
or
Alb3 pp. 543-544   same
or
Alb4 pp. 652-654   same
or
Alb5 pp. 689-690   same

NMWF4 pp. 109-110, 282   same (very brief mentions)

Matthews Neurobiol2 Ch.11 pp. 238-250   heart action potential (includes modulation by NE, ACh)

Aidley4 Ch.21 pp. 385-393   (slightly more advanced, with more detail)
                                                heart action potential, including modulation by NE, ACh; EKG

Hille3: (advanced, but excellent and thorough)
          pp. 131-154   IK's (delayed rectifiers: 'HH' and 'slower'), IA, IK(Ca), Iir
          pp. 158-160   Ih
          pp. 226-228   NE modulation of IK(Ca)
          pp. 228-232   heart action potential (including modulation by NE, ACh for Lect.32)


(for those interested)
Ashcroft pp.89-94, 111-123   (excellent) Long QT syndrome -- examples of inherited 'channelopathies'

(A possibly helpful animation illustrating the relation between the seqeuntial regional activities of the heart,
as described in the Matthews reference, and phases of the typical EKG, as shown in the Aidley reference,
can be found on the Wikipedia Web site's entry Electrical_conduction_system_of_the_heart. Some older
Web browsers may be unable to display it.)